A mimicry of primary amines by bis-secondary diamines as components in the Ugi four-component reaction

Giovanni Battista Giovenzana; Gian Cesare Tron; Stefano Di Paola; Ivan Guglielmo Menegotto; Tracey Pirali

doi:10.1002/anie.200503095

A mimicry of primary amines by bis-secondary diamines as components in the Ugi four-component reaction

Giovanni Battista Giovenzana
, Gian Cesare Tron
, Stefano Di Paola
, Ivan Guglielmo Menegotto
, Tracey Pirali

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Splitting the amine! The Ugi four-component reaction (Ugi 4CR) relies on the presence of a component with a primary amino group. This protocol has been modified by "splitting" the primary amine into two secondary amines. The resulting variant of the Ugi 4CR proceeds with good to excellent yield and widens the versatility of the original multicomponent reaction by enabling variation of the molecular backbone. (Chemical Equation Presented)

Original language	English
Pages (from-to)	1099-1102
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	45
Issue number	7
DOIs	https://doi.org/10.1002/anie.200503095
Publication status	Published - 6 Feb 2006

Keywords

Amines
Isocyanides
Molecular diversity
Multicomponent reactions

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10.1002/anie.200503095

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AU - Di Paola, Stefano

AU - Menegotto, Ivan Guglielmo

AU - Pirali, Tracey

PY - 2006/2/6

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AB - Splitting the amine! The Ugi four-component reaction (Ugi 4CR) relies on the presence of a component with a primary amino group. This protocol has been modified by "splitting" the primary amine into two secondary amines. The resulting variant of the Ugi 4CR proceeds with good to excellent yield and widens the versatility of the original multicomponent reaction by enabling variation of the molecular backbone. (Chemical Equation Presented)

KW - Amines

KW - Isocyanides

KW - Molecular diversity

KW - Multicomponent reactions

UR - https://www.scopus.com/pages/publications/33746321616

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DO - 10.1002/anie.200503095

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ER -

A mimicry of primary amines by bis-secondary diamines as components in the Ugi four-component reaction

Abstract

Keywords

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