A Metabologenomic approach reveals alterations in the gut microbiota of a mouse model of Alzheimer's disease

Francesco Favero, ELETTRA BARBERIS, Mara GAGLIARDI, STEFANO LUIGI ESPINOZA, Liliana Contu, Stefano Gustincich, FRANCESCA BOCCAFOSCHI, CHIARA BORSOTTI, DMITRY LIM, VITO RUBINO, Flavio Mignone, Edoardo Pasolli, MARCELLO MANFREDI, Silvia Zucchelli, Davide CORA', MARCO CORAZZARI

Research output: Contribution to journalArticlepeer-review

Abstract

The key role played by host-microbiota interactions on human health, disease onset and progression, and on host response to treatments has increasingly emerged in the latest decades. Indeed, dysbiosis has been associated to several human diseases such as obesity, diabetes, cancer and also neurodegenerative disease, such as Parkinson, Huntington and Alzheimer's disease (AD), although whether causative, consequence or merely an epiphenomenon is still under investigation. In the present study, we performed a metabologenomic analysis of stool samples from a mouse model of AD, the 3xTgAD. We found a significant change in the microbiota of AD mice compared to WT, with a longitudinal divergence of the F/B ratio, a parameter suggesting a gut dysbiosis. Moreover, AD mice showed a significant decrease of some amino acids, while data integration revealed a dysregulated production of desaminotyrosine (DAT) and dihydro-3-coumaric acid. Collectively, our data show a dysregulated gut microbiota associated to the onset and progression of AD, also indicating that a dysbiosis can occur prior to significant clinical signs, evidenced by early SCFA alterations, compatible with gut inflammation.
Original languageEnglish
Pages (from-to)e0273036
JournalPLoS ONE
Volume17
Issue number8
DOIs
Publication statusPublished - 2022

Keywords

  • Alzheimer Disease
  • Animals
  • Disease Models, Animal
  • Dysbiosis
  • Gastrointestinal Microbiome
  • Humans
  • Mice
  • Neurodegenerative Diseases

Fingerprint

Dive into the research topics of 'A Metabologenomic approach reveals alterations in the gut microbiota of a mouse model of Alzheimer's disease'. Together they form a unique fingerprint.

Cite this