A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

RA Scott, DF Freitag, L Li, AY Chu, P Surendran, R Young, N Grarup, A Stancáková, Y Chen, TV Varga, H Yaghootkar, J Luan, JH Zhao, SM Willems, J Wessel, S Wang, N Maruthur, K Michailidou, A Pirie, der Lee SJ vanC Gillson, Olama AA Al, P Amouyel, L Arriola, D Arveiler, I Aviles-Olmos, B Balkau, A Barricarte, I Barroso, SB Garcia, JC Bis, S Blankenberg, M Boehnke, H Boeing, E Boerwinkle, IB Borecki, J Bork-Jensen, S Bowden, C Caldas, M Caslake, CVD50 consortium, LA Cupples, C Cruchaga, J Czajkowski, Hoed M den, JA Dunn, HM Earl, GB Ehret, E Ferrannini, J Ferrieres, T Foltynie, I Ford, NG Forouhi, F Gianfagna, C Gonzalez, S Grioni, L Hiller, JH Jansson, ME Jørgensen, JW Jukema, R Kaaks, F Kee, ND Kerrison, TJ Key, J Kontto, Z Kote-Jarai, AT Kraja, K Kuulasmaa, J Kuusisto, A Linneberg, C Liu, G Marenne, KL Mohlke, AP Morris, K Muir, M Müller-Nurasyid, PB Munroe, C Navarro, SF Nielsen, PM Nilsson, BG Nordestgaard, CJ Packard, D Palli, S Panico, GM Peloso, M Perola, A Peters, CJ Poole, JR Quirós, O Rolandsson, Carlotta SACERDOTE, V Salomaa, MJ Sánchez, N Sattar, SJ Sharp, R Sims, N Slimani, JA Smith, DJ Thompson, S Trompet, R Tumino, der A DL van, der Schouw YT van, J Virtamo, M Walker, K Walter, GERAD_EC Consortium, Neurology Working Group of the Cohorts for Heart, Research in Genomic Epidemiology (CHARGE) Aging, Alzheimer’s Disease Genetics Consortium, Pancreatic Cancer Cohort Consortium, Prospective Investigation into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD) European, EPIC-InterAct, JE Abraham, LT Amundadottir, JL Aponte, AS Butterworth, J Dupuis, DF Easton, RA Eeles, J Erdmann, PW Franks, TM Frayling, T Hansen, JM Howson, T Jørgensen, J Kooner, M Laakso, C Langenberg, MI McCarthy, JS Pankow, O Pedersen, E Riboli, JI Rotter, D Saleheen, NJ Samani, H Schunkert, P Vollenweider, S O'Rahilly, CHARGE consortium, CHD Exome+ Consortium, CARDIOGRAM Exome Consortium, P Deloukas, J Danesh, MO Goodarzi, S Kathiresan, JB Meigs, MG Ehm, NJ Wareham, DM. Waterworth

Research output: Contribution to journalArticle

Original languageEnglish
JournalScience Translational Medicine
Volume8
Issue number341
DOIs
Publication statusPublished - 2016

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