A curated database of miRNA mediated feed-forward loops involving MYC as master regulator

Mariama Baroudi; Davide Corà; Carla Bosia; Matteo Osella; Michele Caselle

doi:10.1371/journal.pone.0014742

A curated database of miRNA mediated feed-forward loops involving MYC as master regulator

Mariama Baroudi
, Davide Corà
, Carla Bosia
, Matteo Osella
, Michele Caselle

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The MYC transcription factors are known to be involved in the biology of many human cancer types. But little is known about the Myc/microRNAs cooperation in the regulation of genes at the transcriptional and post-transcriptional level. Methodology/Principal Findings: Employing independent databases with experimentally validated data, we identified several mixed microRNA/Transcription Factor Feed-Forward Loops regulated by Myc and characterized completely by experimentally supported regulatory interactions, in human. We then studied the statistical and functional properties of these circuits and discussed in more detail a few interesting examples involving E2F1, PTEN, RB1 and VEGF. Conclusions/Significance: We have assembled and characterized a catalogue of human mixed Transcription Factor/microRNA Feed-Forward Loops, having Myc as master regulator and completely defined by experimentally verified regulatory interactions.

Original language	English
Article number	e14742
Journal	PLoS ONE
Volume	6
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0014742
Publication status	Published - 2011
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1371/journal.pone.0014742

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title = "A curated database of miRNA mediated feed-forward loops involving MYC as master regulator",

abstract = "Background: The MYC transcription factors are known to be involved in the biology of many human cancer types. But little is known about the Myc/microRNAs cooperation in the regulation of genes at the transcriptional and post-transcriptional level. Methodology/Principal Findings: Employing independent databases with experimentally validated data, we identified several mixed microRNA/Transcription Factor Feed-Forward Loops regulated by Myc and characterized completely by experimentally supported regulatory interactions, in human. We then studied the statistical and functional properties of these circuits and discussed in more detail a few interesting examples involving E2F1, PTEN, RB1 and VEGF. Conclusions/Significance: We have assembled and characterized a catalogue of human mixed Transcription Factor/microRNA Feed-Forward Loops, having Myc as master regulator and completely defined by experimentally verified regulatory interactions.",

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T1 - A curated database of miRNA mediated feed-forward loops involving MYC as master regulator

AU - Baroudi, Mariama

AU - Corà, Davide

AU - Bosia, Carla

AU - Osella, Matteo

AU - Caselle, Michele

PY - 2011

Y1 - 2011

N2 - Background: The MYC transcription factors are known to be involved in the biology of many human cancer types. But little is known about the Myc/microRNAs cooperation in the regulation of genes at the transcriptional and post-transcriptional level. Methodology/Principal Findings: Employing independent databases with experimentally validated data, we identified several mixed microRNA/Transcription Factor Feed-Forward Loops regulated by Myc and characterized completely by experimentally supported regulatory interactions, in human. We then studied the statistical and functional properties of these circuits and discussed in more detail a few interesting examples involving E2F1, PTEN, RB1 and VEGF. Conclusions/Significance: We have assembled and characterized a catalogue of human mixed Transcription Factor/microRNA Feed-Forward Loops, having Myc as master regulator and completely defined by experimentally verified regulatory interactions.

AB - Background: The MYC transcription factors are known to be involved in the biology of many human cancer types. But little is known about the Myc/microRNAs cooperation in the regulation of genes at the transcriptional and post-transcriptional level. Methodology/Principal Findings: Employing independent databases with experimentally validated data, we identified several mixed microRNA/Transcription Factor Feed-Forward Loops regulated by Myc and characterized completely by experimentally supported regulatory interactions, in human. We then studied the statistical and functional properties of these circuits and discussed in more detail a few interesting examples involving E2F1, PTEN, RB1 and VEGF. Conclusions/Significance: We have assembled and characterized a catalogue of human mixed Transcription Factor/microRNA Feed-Forward Loops, having Myc as master regulator and completely defined by experimentally verified regulatory interactions.

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DO - 10.1371/journal.pone.0014742

M3 - Article

SN - 1932-6203

VL - 6

JO - PLoS ONE

JF - PLoS ONE

IS - 3

M1 - e14742

ER -

A curated database of miRNA mediated feed-forward loops involving MYC as master regulator

Abstract

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