A concise entry into nonsymmetrical alkyl polyamines

Tracey Pirali; Grazia Callipari; Emanuela Ercolano; Armando A. Genazzani; Giovanni Battista Giovenzana; Gian Cesare Tron

doi:10.1021/ol801612r

A concise entry into nonsymmetrical alkyl polyamines

Tracey Pirali, Grazia Callipari, Emanuela Ercolano, Armando A. Genazzani, Giovanni Battista Giovenzana, Gian Cesare Tron

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

(Chemical Equation Presented) The synthesis of nonsymmetrical polyamines (PAs) has, up to now, been problematic due to lengthy synthetic procedures, lack of regioselectivity, and very poor atom economy. An innovative synthetic protocol for nonsymmetrical PAs using a modified Ugi reaction (N-split Ugi) which simplifies the synthesis of these tricky compounds is described. We believe that this new synthesis may open the door for the generation of new and pharmacologically active PAs.

Original language	English
Pages (from-to)	4199-4202
Number of pages	4
Journal	Organic Letters
Volume	10
Issue number	19
DOIs	https://doi.org/10.1021/ol801612r
Publication status	Published - 2008

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10.1021/ol801612r

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abstract = "(Chemical Equation Presented) The synthesis of nonsymmetrical polyamines (PAs) has, up to now, been problematic due to lengthy synthetic procedures, lack of regioselectivity, and very poor atom economy. An innovative synthetic protocol for nonsymmetrical PAs using a modified Ugi reaction (N-split Ugi) which simplifies the synthesis of these tricky compounds is described. We believe that this new synthesis may open the door for the generation of new and pharmacologically active PAs.",

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AU - Pirali, Tracey

AU - Callipari, Grazia

AU - Ercolano, Emanuela

AU - Genazzani, Armando A.

AU - Giovenzana, Giovanni Battista

AU - Tron, Gian Cesare

PY - 2008

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AB - (Chemical Equation Presented) The synthesis of nonsymmetrical polyamines (PAs) has, up to now, been problematic due to lengthy synthetic procedures, lack of regioselectivity, and very poor atom economy. An innovative synthetic protocol for nonsymmetrical PAs using a modified Ugi reaction (N-split Ugi) which simplifies the synthesis of these tricky compounds is described. We believe that this new synthesis may open the door for the generation of new and pharmacologically active PAs.

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A concise entry into nonsymmetrical alkyl polyamines

Abstract

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