A Chemical Strategy for the Preparation of Multimodified Peptide Imaging Probes

Lucia De Rosa; Ivan Hawala; Rossella Di Stasi; Rachele Stefania; Martina Capozza; Donatella Nava; Luca Domenico D’Andrea

doi:10.1021/acs.joc.3c00014

A Chemical Strategy for the Preparation of Multimodified Peptide Imaging Probes

Lucia De Rosa, Ivan Hawala, Rossella Di Stasi, Rachele Stefania, Martina Capozza, Donatella Nava, Luca Domenico D’Andrea

Research output: Contribution to journal › Article › peer-review

Abstract

Multimodality probes appear of great interest for innovative imaging applications in disease diagnosis. Herein, we present a chemical strategy enabling site-specific double-modification and cyclization of a peptide probe exploiting native chemical ligation (NCL) and thiol-maleimide addition. The synthetic strategy is straightforward and of general applicability for the development of double-labeled peptide multimodality probes.

Original language	English
Pages (from-to)	4546-4553
Number of pages	8
Journal	Journal of Organic Chemistry
Volume	88
Issue number	7
DOIs	https://doi.org/10.1021/acs.joc.3c00014
Publication status	Published - 7 Apr 2023
Externally published	Yes

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10.1021/acs.joc.3c00014

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title = "A Chemical Strategy for the Preparation of Multimodified Peptide Imaging Probes",

abstract = "Multimodality probes appear of great interest for innovative imaging applications in disease diagnosis. Herein, we present a chemical strategy enabling site-specific double-modification and cyclization of a peptide probe exploiting native chemical ligation (NCL) and thiol-maleimide addition. The synthetic strategy is straightforward and of general applicability for the development of double-labeled peptide multimodality probes.",

author = "{De Rosa}, Lucia and Ivan Hawala and {Di Stasi}, Rossella and Rachele Stefania and Martina Capozza and Donatella Nava and D{\textquoteright}Andrea, {Luca Domenico}",

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AU - De Rosa, Lucia

AU - Hawala, Ivan

AU - Di Stasi, Rossella

AU - Stefania, Rachele

AU - Capozza, Martina

AU - Nava, Donatella

AU - D’Andrea, Luca Domenico

PY - 2023/4/7

Y1 - 2023/4/7

N2 - Multimodality probes appear of great interest for innovative imaging applications in disease diagnosis. Herein, we present a chemical strategy enabling site-specific double-modification and cyclization of a peptide probe exploiting native chemical ligation (NCL) and thiol-maleimide addition. The synthetic strategy is straightforward and of general applicability for the development of double-labeled peptide multimodality probes.

AB - Multimodality probes appear of great interest for innovative imaging applications in disease diagnosis. Herein, we present a chemical strategy enabling site-specific double-modification and cyclization of a peptide probe exploiting native chemical ligation (NCL) and thiol-maleimide addition. The synthetic strategy is straightforward and of general applicability for the development of double-labeled peptide multimodality probes.

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DO - 10.1021/acs.joc.3c00014

M3 - Article

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SP - 4546

EP - 4553

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 7

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A Chemical Strategy for the Preparation of Multimodified Peptide Imaging Probes

Abstract

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