A calix[4]arene GdIII complex endowed with high stability, relaxivity, and binding affinity to serum albumin

Silvio Aime; Alessandro Barge; Mauro Botta; Alessandro Casnati; Marco Fragai; Claudio Luchinat; Rocco Ungaro

doi:10.1002/1521-3773(20011217)40:24<4737::AID-ANIE4737>3.0.CO;2-W

A calix[4]arene Gd^III complex endowed with high stability, relaxivity, and binding affinity to serum albumin

Silvio Aime
, Alessandro Barge
, Mauro Botta
, Alessandro Casnati
, Marco Fragai
, Claudio Luchinat
, Rocco Ungaro

Department of Science and Technological Innovation

Research output: Contribution to journal › Article › peer-review

Abstract

Contrasting calixarenes: Thermodynamically stable and water-soluble calix[4]arene-Ln^III (see picture) complexes may represent a new class of relaxation (Ln = Gd) or luminescent (Ln = Eu, Tb) probes for biomedical studies. The first complete characterization of one of these complexes in water is reported. The Gd^III chelate shows a strong binding affinity with human serum albumin as a result of the cooperative effects of hydrophobic interaction and coordination by donors groups on the protein.

Original language	English
Pages (from-to)	4737-4739
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	40
Issue number	24
DOIs	https://doi.org/10.1002/1521-3773(20011217)40:24<4737::AID-ANIE4737>3.0.CO;2-W
Publication status	Published - 17 Dec 2001

Keywords

Calixarenes
Contrast agents
Coordination chemistry
Lanthanides
NMR spectroscopy

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10.1002/1521-3773(20011217)40:24<4737::AID-ANIE4737>3.0.CO;2-W

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title = "A calix[4]arene GdIII complex endowed with high stability, relaxivity, and binding affinity to serum albumin",

abstract = "Contrasting calixarenes: Thermodynamically stable and water-soluble calix[4]arene-LnIII (see picture) complexes may represent a new class of relaxation (Ln = Gd) or luminescent (Ln = Eu, Tb) probes for biomedical studies. The first complete characterization of one of these complexes in water is reported. The GdIII chelate shows a strong binding affinity with human serum albumin as a result of the cooperative effects of hydrophobic interaction and coordination by donors groups on the protein.",

keywords = "Calixarenes, Contrast agents, Coordination chemistry, Lanthanides, NMR spectroscopy",

author = "Silvio Aime and Alessandro Barge and Mauro Botta and Alessandro Casnati and Marco Fragai and Claudio Luchinat and Rocco Ungaro",

year = "2001",

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day = "17",

doi = "10.1002/1521-3773(20011217)40:24<4737::AID-ANIE4737>3.0.CO;2-W",

language = "English",

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T1 - A calix[4]arene GdIII complex endowed with high stability, relaxivity, and binding affinity to serum albumin

AU - Aime, Silvio

AU - Barge, Alessandro

AU - Botta, Mauro

AU - Casnati, Alessandro

AU - Fragai, Marco

AU - Luchinat, Claudio

AU - Ungaro, Rocco

PY - 2001/12/17

Y1 - 2001/12/17

N2 - Contrasting calixarenes: Thermodynamically stable and water-soluble calix[4]arene-LnIII (see picture) complexes may represent a new class of relaxation (Ln = Gd) or luminescent (Ln = Eu, Tb) probes for biomedical studies. The first complete characterization of one of these complexes in water is reported. The GdIII chelate shows a strong binding affinity with human serum albumin as a result of the cooperative effects of hydrophobic interaction and coordination by donors groups on the protein.

AB - Contrasting calixarenes: Thermodynamically stable and water-soluble calix[4]arene-LnIII (see picture) complexes may represent a new class of relaxation (Ln = Gd) or luminescent (Ln = Eu, Tb) probes for biomedical studies. The first complete characterization of one of these complexes in water is reported. The GdIII chelate shows a strong binding affinity with human serum albumin as a result of the cooperative effects of hydrophobic interaction and coordination by donors groups on the protein.

KW - Calixarenes

KW - Contrast agents

KW - Coordination chemistry

KW - Lanthanides

KW - NMR spectroscopy

UR - https://www.scopus.com/pages/publications/0035905351

U2 - 10.1002/1521-3773(20011217)40:24<4737::AID-ANIE4737>3.0.CO;2-W

DO - 10.1002/1521-3773(20011217)40:24<4737::AID-ANIE4737>3.0.CO;2-W

M3 - Article

SN - 1433-7851

VL - 40

SP - 4737

EP - 4739

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 24

ER -

A calix[4]arene Gd^III complex endowed with high stability, relaxivity, and binding affinity to serum albumin

Abstract

Keywords

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