Abstract
Contrasting calixarenes: Thermodynamically stable and water-soluble calix[4]arene-LnIII (see picture) complexes may represent a new class of relaxation (Ln = Gd) or luminescent (Ln = Eu, Tb) probes for biomedical studies. The first complete characterization of one of these complexes in water is reported. The GdIII chelate shows a strong binding affinity with human serum albumin as a result of the cooperative effects of hydrophobic interaction and coordination by donors groups on the protein.
Original language | English |
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Pages (from-to) | 4737-4739 |
Number of pages | 3 |
Journal | Angewandte Chemie - International Edition |
Volume | 40 |
Issue number | 24 |
DOIs | |
Publication status | Published - 17 Dec 2001 |
Keywords
- Calixarenes
- Contrast agents
- Coordination chemistry
- Lanthanides
- NMR spectroscopy