A calix[4]arene GdIII complex endowed with high stability, relaxivity, and binding affinity to serum albumin

Silvio Aime, Alessandro Barge, Mauro Botta, Alessandro Casnati, Marco Fragai, Claudio Luchinat, Rocco Ungaro

Research output: Contribution to journalArticlepeer-review

Abstract

Contrasting calixarenes: Thermodynamically stable and water-soluble calix[4]arene-LnIII (see picture) complexes may represent a new class of relaxation (Ln = Gd) or luminescent (Ln = Eu, Tb) probes for biomedical studies. The first complete characterization of one of these complexes in water is reported. The GdIII chelate shows a strong binding affinity with human serum albumin as a result of the cooperative effects of hydrophobic interaction and coordination by donors groups on the protein.

Original languageEnglish
Pages (from-to)4737-4739
Number of pages3
JournalAngewandte Chemie - International Edition
Volume40
Issue number24
DOIs
Publication statusPublished - 17 Dec 2001

Keywords

  • Calixarenes
  • Contrast agents
  • Coordination chemistry
  • Lanthanides
  • NMR spectroscopy

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