Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 14 Life Below Water
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Dive into the research topics where SILVIO APRILE is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Old dog, new tricks. Inhibiting HDACs using isonitriles. Novel epigenetic drugs against triple negative breast cancer
TRON, G. C. (PI), MANFREDI, M. (CoI), GROLLA, A. (CoI) & APRILE, S. (CoI)
AIRC - Fondazione AIRC per la Ricerca sul Cancro
2/01/24 → 31/03/29
Project: Research
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iSonitriles: innovative pHarmacOphoric GroUps as aNtibacterial agents against multidrug resistance pathogenic bacteria (SHOGUN)
TRON, G. C. (PI), APRILE, S. (CoI) & FRACCHIA, L. (CoI)
MUR - Ministero dell'Università e Ricerca
16/10/23 → 16/10/25
Project: Research
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Bacillus subtilis AC7 Fermentation on Rice Husk Substrate: A Sustainable Approach for Lipopeptide Biosurfactant Production
Sansotera, A. C., Ceresa, C., Trejo, C. F., Ferrandi, A., Allegrone, G., APRILE, S., RINALDI, M., MOREL, S. & FRACCHIA, L., 2026, In: Microorganisms. 14, 6Research output: Contribution to journal › Article › peer-review
Open Access -
Development of PROTACs Targeting the Moonlighting Enzyme Nicotinamide Phosphoribosyltransferase (NAMPT) for Breast Cancer Therapy
Galli, U., Moro, M., Balestrero, F. C., Colombo, G., Koten, M., Roncaglio, B., Genazzani, A. A., Aprile, S., Massarotti, A., Orsomando, G., Pirali, T. & Grolla, A. A., 12 Mar 2026, In: Journal of Medicinal Chemistry. 69, 5, p. 5259-5290 32 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Discovery of a Dual IDO1/TDO Inhibitor That Modulates Enzymatic Activity and IDO1/SHP-2 Signaling
Rezzi, S. J., Butticè, A., Villani, S., Lesca, G., Rossini, S., Panfili, E., Mazzoletti, D., Bari, E., Violante, D., Serafini, M., Massarotti, A., Orabona, C., Pallotta, M. T., Aprile, S., Fallarini, S., Del Grosso, E., Di Martino, R. M. C., Miggiano, R. & Pirali, T., 13 Aug 2026, In: Journal of Medicinal Chemistry. 69, 15, p. 18336-18363 28 p.Research output: Contribution to journal › Article › peer-review
Open Access -
An adamantane-based ligand as a novel chemical tool for thermosensory TRPM8 channel therapeutic modulation
Lamberti, A., Aprile, S., Cabañero, D., Travagin, F., Butron, L., Fernández-Ballester, G., Tron, G. C., Fernández-Carvajal, A., Ferrer-Montiel, A. & Galli, U., Jul 2025, In: FEBS Journal. 292, 13, p. 3449-3476 28 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Exploring the pharmaceutical potential of ammonium organotrifluoroborate functional group: Comprehensive chemical, metabolic, and plasma stability evaluation
Villani, S., IMPERIO, D., PANZA, L., Confalonieri, L., FALLARINI, S., APRILE, S. & DEL GROSSO, E., 2024, In: European Journal of Medicinal Chemistry. 279Research output: Contribution to journal › Article › peer-review