Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Leveraging new chemical modalities for reprogramming IDO1 half-life in cancer immunotherapy
PIRALI, T. (PI), FALLARINI, S. (CoI), DEL GROSSO, E. (CoI), DI MARTINO, R. M. C. (CoI), MASSAROTTI, A. (CoI) & MIGGIANO, R. (CoI)
AIRC - Fondazione AIRC per la Ricerca sul Cancro
2/01/24 → 31/03/29
Project: Research
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Deciphering the mechanistic details of Mycobacterium tuberculosis nucleotide excision repair and related proteins as key players of bacterial persistence and adaptation: structure-based insights for anti-evolution drug design
MIGGIANO, R. (PI)
MUR - Ministero dell'Università e Ricerca
30/11/23 → 29/11/25
Project: Research
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An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent
Alberti, M., Poli, G., Broggini, L., Sainas, S., RIZZI, M., Boschi, D., FERRARIS, D. M., Martino, E., Ricagno, S., Tuccinardi, T., Lolli, M. L. & MIGGIANO, R., 2024, In: ACTA CRYSTALLOGRAPHICA. SECTION D, STRUCTURAL BIOLOGY. 80, 6Research output: Contribution to journal › Article › peer-review
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ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca2+ uptake and oxidative metabolism
Dematteis, G., Tapella, L., Casali, C., Talmon, M., Tonelli, E., Reano, S., Ariotti, A., Pessolano, E., Malecka, J., Chrostek, G., Kulkovienė, G., Umbrasas, D., Distasi, C., Grilli, M., Ladds, G., Filigheddu, N., Fresu, L. G., Mikoshiba, K., Matute, C. & Ramos-Gonzalez, P. & 8 others, , Dec 2024, In: Communications Biology. 7, 1, 1294.Research output: Contribution to journal › Article › peer-review
Open Access -
Identification of a Compound Inhibiting Both the Enzymatic and Nonenzymatic Functions of Indoleamine 2,3-Dioxygenase 1
Panfili, E., Rezzi, S. J., Adamo, A., Mazzoletti, D., Massarotti, A., Miggiano, R., Fallarini, S., Ambrosino, S., Coletti, A., Molinaro, P., Milella, M., Paiella, S., Macchiarulo, A., Ugel, S., Pirali, T. & Pallotta, M. T., 11 Oct 2024, In: ACS Pharmacology and Translational Science. 7, 10, p. 3056-3070 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor
Alberti, M., Sainas, S., Ronchi, E., Lolli, M. L., Boschi, D., RIZZI, M., FERRARIS, D. M. & MIGGIANO, R., 2023, In: FEBS Letters.Research output: Contribution to journal › Article › peer-review
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Cryo-EM-based structural investigation of Mycobacterium tuberculosis Nucleotide Excision Repair
Marianna, G., Antonio, C., Martino, B., ROSSI, F., RIZZI, M. & MIGGIANO, R., 2023.Research output: Contribution to conference › Paper › peer-review